2008 |
Monine, M.I. and Haugh, J.M. (2008).
Cell population-based model of dermal wound invasion with heterogeneous
intracellular signaling properties.
Cell Adhesion & Migration, accepted. |
|
Haugh, J.M. (2008).
Cells get in shape for a crawl.
Nature, 453: 461-462. (News & Views) (doi:10.1038/453461a) |
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Monine, M.I. and Haugh, J.M. (2008).
Signal transduction at point-blank range: analysis of a spatial coupling mechanism for pathway crosstalk.
Biophysical Journal, accepted. (doi:10.1529/biophysj.108.128892) |
|
Comfort, K.K. and Haugh, J.M. (2008).
Combinatorial signal transduction responses mediated by interleukin-2 and -4 receptors in a helper TH2 cell line.
Cellular and Molecular Bioengineering, in press. (doi:10.1007/s12195-008-0015-9) |
|
Barua, D., Faeder, J.R., and Haugh, J.M. (2008).
Computational models of tandem Src homology 2 domain interactions and application to phosphoinositide 3-kinase.
Journal of Biological Chemistry, 283: 7338-7345. (doi:10.1074/jbc.M708359200) |
|
DeLisa, M. and Haugh, J. (2008).
First International Conference on Biomolecular Engineering (ICBE).
Biotechnology Progress, 24: 1. (Editorial) (doi:10.1021/bp0704889)
See the special issue on the 1st ICBE |
|
Haugh, J.M. (2008).
Mathematical modeling of biological signaling networks.
In Wiley Encyclopedia of Chemical Biology. John Wiley & Sons. (Review) (doi:10.1002/9780470048672.wecb646) |
2007 |
Haugh, J.M. (2007).
Membrane-binding/modification model of signaling protein activation and
analysis of its control by cell morphology.
Biophysical Journal, 92: L93-L95. (doi:10.1529/biophysj.107.105213) |
|
Haugh, J.M. and Kelly, R.M. (2007).
Biochemical Engineering.
In Encyclopedia of Science & Technology, 10th Ed. McGraw-Hill. |
|
Barua, D., Faeder, J.R., and Haugh, J.M. (2007).
Structure-based kinetic models of modular signaling protein function:
Focus on Shp2.
Biophysical Journal, 92: 2290-2300. (doi:10.1529/biophysj.106.093484) |
|
Haugh, J.M. and Weiger, M.C. (2007).
Modeling intracellular signal transduction processes.
In Chemical Biology: From Small Molecules to Systems Biology and Drug Design,
S. Schreiber, T. Kapoor, & G. Wess, eds. Wiley-VCH, Vol. 3, pp. 1061-1081. (Review) ISBN-10: 3-527-31150-5 |
|
2006 |
Schneider, I.C. and Haugh, J.M. (2006).
Mechanisms of gradient sensing and chemotaxis:
Conserved pathways, diverse regulation.
Cell Cycle, 5: 1130-1134. (Extra View) (link) |
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Haugh, J.M. and Schneider, I.C. (2006).
Effectiveness factor for spatial gradient sensing in living cells.
Chemical Engineering Science, 61: 5603-5611. (doi:10.1016/j.ces.2006.04.041) |
|
Haugh, J.M. (2006).
Deterministic model of dermal wound invasion incorporating receptor-mediated signal transduction and spatial gradient sensing.
Biophysical Journal, 90: 2297-2308. (doi:10.1529/biophysj.105.077610) |
|
Kaur, H.*, Park, C.S.*, Lewis, J.M., and Haugh, J.M. (2006). (*co-first authors).
Quantitative model of Ras/phosphoinositide 3-kinase signalling cross-talk
based on co-operative molecular assembly.
Biochemical Journal, 393: 235-243. (doi:10.1042/BJ20051022) |
|
2005 |
Schneider, I.C. and Haugh, J.M. (2005).
Quantitative elucidation of a distinct spatial gradient-sensing mechanism
in fibroblasts.
Journal of Cell Biology, 171: 883-892. (doi:10.1083/jcb.200509028)
Featured in JCB Featured in the Cell Migration Gateway |
|
Monine, M.I. and Haugh, J.M. (2005).
Reactions on cell membranes: Comparison of continuum theory and
Brownian dynamics simulations.
Journal of Chemical Physics, 123: 074908 (6 pages). (doi:10.1063/1.2000236) |
|
Schneider, I.C., Parrish, E.M., and Haugh, J.M. (2005).
Spatial analysis of 3' phosphoinositide signaling in living fibroblasts,
III: Influence of cell morphology and morphological polarity.
Biophysical Journal, 89: 1420-1430. (doi:10.1529/biophysj.105.061218) |
|
2004 |
Haugh, J.M. (2004).
Mathematical model of human growth hormone (hGH)-stimulated cell proliferation explains the efficacy of hGH variants as receptor agonists or antagonists.
Biotechnology Progress, 20: 1337-1344. (doi:10.1021/bp0499101) |
|
Haugh, J.M., Schneider, I.C., and Lewis, J.M. (2004).
On the cross-regulation of protein tyrosine phosphatases and receptor tyrosine kinases in intracellular signaling.
Journal of Theoretical Biology, 230: 119-132. (doi:10.1016/j.jtbi.2004.04.023) |
|
Schneider, I.C. and Haugh, J.M. (2004).
Spatial analysis of 3' phosphoinositide signaling in living fibroblasts:
II. Parameter estimates for individual cells from experiments.
Biophysical Journal, 86: 599-608. (link) |
|
Haugh, J.M. and Schneider, I.C. (2004).
Spatial analysis of 3' phosphoinositide signaling in living fibroblasts:
I. Uniform stimulation model and bounds on dimensionless groups.
Biophysical Journal, 86: 589-598. (link) |
|
2003 |
Park, C.S., Schneider, I.C., and Haugh, J.M. (2003).
Kinetic analysis of platelet-derived growth factor receptor/phosphoinositide 3-kinase/Akt signaling in fibroblasts.
Journal of Biological Chemistry, 278: 37064-37072. (link) |
|
2002 |
Haugh, J.M. (2002).
Localization of receptor-mediated signal transduction pathways: The inside story.
Molecular Interventions, 2: 292-307. (Review) (link) |
|
Haugh, J.M. (2002).
A unified model for signal transduction reactions in cellular membranes.
Biophysical Journal, 82: 591-604. (link) |
|
Haugh, J.M. and Meyer, T. (2002).
Active EGF receptors have limited access to PI(4,5)P2 in endosomes:
implications for phospholipase C and PI 3-kinase signaling.
Journal of Cell Science, 115: 303-310. (link) |
|
1997-2000 |
Haugh, J.M., Codazzi, F., Teruel, M., and Meyer, T. (2000).
Spatial sensing in fibroblasts mediated by 3' phosphoinositides.
Journal of Cell Biology, 151: 1269-1279. (doi:10.1083/jcb.151.6.1269)
Featured in JCB |
|
Haugh, J.M., Wells, A., and Lauffenburger, D.A. (2000).
Mathematical modeling of epidermal growth factor receptor signaling through the phospholipase C pathway: Mechanistic insights and predictions for molecular interventions.
Biotechnology & Bioengineering, 70: 225-238. (link) |
|
Haugh, J.M., Huang, A.C., Wiley, H.S., Wells, A., and Lauffenburger, D.A. (1999).
Internalized epidermal growth factor receptors participate in the activation of p21(ras) in fibroblasts.
Journal of Biological Chemistry, 274: 34350-34360. (link) |
|
Haugh, J.M., Schooler, K., Wells, A., Wiley, H.S., and Lauffenburger, D.A. (1999).
Effect of epidermal growth factor receptor internalization on regulation of the phospholipase C-γ1 signaling pathway.
Journal of Biological Chemistry, 274: 8958-8965. (link) |
|
Lauffenburger, D.A., Fallon, E.F. and Haugh, J.M. (1998).
Scratching the (cell) surface: Cytokine engineering for improved ligand/receptor trafficking dynamics.
Chemistry & Biology, 5: R257-R263. (Review) (doi:10.1016/S1074-5521(98)90110-7) |
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Haugh, J.M. and Lauffenburger, D.A. (1998).
Analysis of receptor internalization as a mechanism for modulating signal transduction.
Journal of Theoretical Biology, 195: 187-218. (doi:10.1006/jtbi.1998.0791) |
|
Haugh, J.M. and Lauffenburger, D.A. (1997).
Physical modulation of intracellular signaling processes by locational regulation.
Biophysical Journal, 72: 2014-2031. (link to PubMed Central) |
