SEMINAR
DEPARTMENT OF CHEMICAL AND BIOMOLECULAR ENGINEERING
NORTH CAROLINA STATE UNIVERSITY
BTEC Rm 135, 10 AM
Dissecting the hierarchy of cellular processes underpinning recombinant monoclonal antibody production by mammalian cells
Dr. David James
University of Sheffield, UK
BTEC Rm 135, 10 AM
Despite the value and therapeutic importance of MAb products, it is still uncertain how engineered mammalian cell factories coordinate multiple dynamic cellular processes to most efficiently manufacture the product. Does control of flux from integrated recombinant gene to secreted product vary between cell lines or through manufacturing processes? In this presentation I will discuss how we can use a continuum of understanding from molecular cell biology to MAb manufacturing performance in vitro to rationally generate improved cell-based manufacturing platforms.