SEMINAR
DEPARTMENT OF CHEMICAL AND BIOMOLECULAR ENGINEERING
NORTH CAROLINA STATE UNIVERSITY
1011 EB1 - 10:45 AM
Development and Application of Chemical and Instrumental Approaches Directed at Biomarker Discovery
Dr. David Muddiman
Chemistry
North Carolina State University
Abstract
This presentation will detail our efforts over the past decade to integrate novel chemical and instrumental approaches with medical research. Briefly, hybrid ionization sources will be discussed when coupled to Fourier transform mass spectrometry for tissue imaging applications, air amplifiers to improve capture efficiency of electrospray droplets at ambient pressure, and chemical approaches to improve the ionization efficiency of peptides and glycans. Our efforts are largely directed at cancer biomarker discovery although these approaches can be applied to address a diverse range of contemporary questions.
Biography
David C. Muddiman is currently a Professor of Chemistry, Founder and Director of the W.M. Keck FT-ICR Mass Spectrometry Laboratory, and Director of the Mass Spectrometry Facility at North Carolina State University in Raleigh, NC. Prior to moving his research group to North Carolina State University, David was a Professor of Biochemistry and Molecular Biology and Director of the Mayo Proteomics Research Center at the Mayo Clinic College of Medicine in Rochester, MN. Prior to his appointment at the Mayo Clinic, David was an Associate Professor of Chemistry at Virginia Commonwealth University where he began his academic career as an assistant professor in 1997 with an adjunct appointment in the Department of Biochemistry & Molecular Biophysics where he was also a member of the Massey Cancer Center. David was born in Long Beach, CA in 1967 but spent most of his formidable years in a small town in Pennsylvania. David received his B.S. in chemistry from Gannon University (Erie, PA) in 1990 and his Ph.D. in Analytical Chemistry from the University of Pittsburgh in 1995 under the auspices of David M. Hercules. He then was a Department of Energy Postdoctoral Fellow at Pacific Northwest National Laboratory in the Environmental Molecular Sciences Laboratory working with Richard D. Smith from 1995-1997. David has served on over 35 NIH study sections since 1999 and reviews for over 30 scientific journals. He has been a guest editor for Analytical and Bioanalytical Chemistry, Mass Spectrometry Reviews, the Journal of the American Society for Mass Spectrometry and the Internal Journal of Mass Spectrometry. He currently serves on the Editorial Advisory Board of Mass Spectrometry Reviews, Journal of Proteome Research, Rapid Communications in Mass Spectrometry, Journal of the American Society for Mass Spectrometry, Advances in Physical Chemistry, and the Journal of Chromatography B. He also serves on the advisory board of the National Science Foundation FT-ICR Mass Spectrometry Laboratory, National High Magnetic Field Laboratory, Florida State University and the Yale/NIDA Neuroproteomics Center, Yale University. His group has presented over 350 invited lectures and presentations at national and international meetings, has published over 140 peer-reviewed papers, and has received one US patent with two more pending. He is the recipient of the 2009 NCSU Alumni Outstanding Research Award, the 2004 ACS Arthur F. Findeis Award, the 1999 American Society for Mass Spectrometry Research Award, and the Safford Award, University of Pittsburgh, for Excellence in Teaching.